CASE STUDY Hodgkin and Reed-Sternberg cells in bone marrow aspirations of a patient with advanced classical Hodgkin lymphoma
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چکیده
INTRODUCTION Hodgkin Lymphoma (HL) is a group of lymphomas of mainly nodal origin with similar clinical and histological features (1). HL encompasses 95% of classical Hodgkin lymphomas (CHL) and the rest are of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). These two entities differ in their aetiology, clinical features, histopathological features, immunophenotype and molecular genetic features. NLPHL is an uncommon monoclonal B cell neoplasm characterized by large neoplastic cells known as popcorn or lymphocyte predominant cells (LP cells) in an inflammatory background. NLPHL is considered to be of germinal centre B-cell origin. It is managed differently from classical HL. The prognosis is good; however, late relapses and transformation to high grade non-Hodgkin lymphoma can occur (1,2).
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